Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.
Identifieur interne : 000275 ( Main/Exploration ); précédent : 000274; suivant : 000276Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.
Auteurs : Michael Nambozi ; Modest Mulenga ; Tinto Halidou ; Harry Tagbor ; Victor Mwapasa ; Linda Kalilani Phiri ; Gertrude Kalanda ; Innocent Valea ; Maminata Traore ; David Mwakazanga ; Yves Claeys ; Céline Schurmans ; Maaike De Crop ; Joris Menten ; Raffaella Ravinetto ; Kamala Thriemer ; Jean-Pierre Van Geertruyden ; Theonest Mutabingwa ; Umberto D'Alessandro [Belgique]Source :
- Reproductive health [ 1742-4755 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Amodiaquine (effets indésirables), Amodiaquine (usage thérapeutique), Antipaludiques (effets indésirables), Antipaludiques (usage thérapeutique), Artémisinines (effets indésirables), Artémisinines (usage thérapeutique), Association médicamenteuse, Burkina, Complications parasitaires de la grossesse (traitement médicamenteux), Développement foetal (), Effets différés de l'exposition prénatale aux facteurs de risque, Femelle, Fluorènes (effets indésirables), Fluorènes (usage thérapeutique), Ghana, Grossesse, Humains, Malawi, Méfloquine (effets indésirables), Méfloquine (usage thérapeutique), Nouveau-né, Paludisme (traitement médicamenteux), Placentation (), Poids de naissance (), Quinoléines (effets indésirables), Quinoléines (usage thérapeutique), Zambie, Éthanolamines (effets indésirables), Éthanolamines (usage thérapeutique), Études de suivi.
- MESH :
- effets indésirables : Amodiaquine, Antipaludiques, Artémisinines, Fluorènes, Méfloquine, Quinoléines, Éthanolamines.
- traitement médicamenteux : Complications parasitaires de la grossesse, Paludisme.
- usage thérapeutique : Amodiaquine, Antipaludiques, Artémisinines, Fluorènes, Méfloquine, Quinoléines, Éthanolamines.
- Adulte, Association médicamenteuse, Burkina, Développement foetal, Effets différés de l'exposition prénatale aux facteurs de risque, Femelle, Ghana, Grossesse, Humains, Malawi, Nouveau-né, Placentation, Poids de naissance, Zambie, Études de suivi.
- Wicri :
- geographic : Burkina Faso, Ghana, Malawi, Zambie.
English descriptors
- KwdEn :
- Adult, Amodiaquine (adverse effects), Amodiaquine (therapeutic use), Antimalarials (adverse effects), Antimalarials (therapeutic use), Artemisinins (adverse effects), Artemisinins (therapeutic use), Birth Weight (drug effects), Burkina Faso, Drug Combinations, Ethanolamines (adverse effects), Ethanolamines (therapeutic use), Female, Fetal Development (drug effects), Fluorenes (adverse effects), Fluorenes (therapeutic use), Follow-Up Studies, Ghana, Humans, Infant, Newborn, Malaria (drug therapy), Malawi, Mefloquine (adverse effects), Mefloquine (therapeutic use), Placentation (drug effects), Pregnancy, Pregnancy Complications, Parasitic (drug therapy), Prenatal Exposure Delayed Effects, Quinolines (adverse effects), Quinolines (therapeutic use), Zambia.
- MESH :
- chemical , adverse effects : Amodiaquine, Antimalarials, Artemisinins, Ethanolamines, Fluorenes, Mefloquine, Quinolines.
- chemical , therapeutic use : Amodiaquine, Antimalarials, Artemisinins, Ethanolamines, Fluorenes, Mefloquine, Quinolines.
- geographic : Burkina Faso, Drug Combinations, Ghana, Malawi, Zambia.
- drug effects : Birth Weight, Fetal Development, Placentation.
- drug therapy : Malaria, Pregnancy Complications, Parasitic.
- Adult, Female, Follow-Up Studies, Humans, Infant, Newborn, Pregnancy, Prenatal Exposure Delayed Effects.
Abstract
Asymptomatic and symptomatic malaria during pregnancy has consequences for both mother and her offspring. Unfortunately, there is insufficient information on the safety and efficacy of most antimalarials in pregnancy. Indeed, clinical trials assessing antimalarial treatments systematically exclude pregnancy for fear of teratogenicity and embryotoxicity. The little available information originates from South East Asia while in sub-Saharan Africa such information is still limited and needs to be provided.
DOI: 10.1186/1742-4755-12-5
PubMed: 25592254
Affiliations:
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Le document en format XML
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Jean Pierre" sort="Van Geertruyden, Jean Pierre" uniqKey="Van Geertruyden J" first="Jean-Pierre" last="Van Geertruyden">Jean-Pierre Van Geertruyden</name></author><author><name sortKey="Mutabingwa, Theonest" sort="Mutabingwa, Theonest" uniqKey="Mutabingwa T" first="Theonest" last="Mutabingwa">Theonest Mutabingwa</name></author><author><name sortKey="D Alessandro, Umberto" sort="D Alessandro, Umberto" uniqKey="D Alessandro U" first="Umberto" last="D'Alessandro">Umberto D'Alessandro</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Tropical Medicine, Antwerp, Belgium. udalessandro@mrc.gm.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute of Tropical Medicine, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author></analytic><series><title level="j">Reproductive health</title><idno type="eISSN">1742-4755</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Amodiaquine (adverse effects)</term><term>Amodiaquine (therapeutic use)</term><term>Antimalarials (adverse effects)</term><term>Antimalarials (therapeutic use)</term><term>Artemisinins (adverse effects)</term><term>Artemisinins (therapeutic use)</term><term>Birth Weight (drug effects)</term><term>Burkina Faso</term><term>Drug Combinations</term><term>Ethanolamines (adverse effects)</term><term>Ethanolamines (therapeutic use)</term><term>Female</term><term>Fetal Development (drug effects)</term><term>Fluorenes (adverse effects)</term><term>Fluorenes (therapeutic use)</term><term>Follow-Up Studies</term><term>Ghana</term><term>Humans</term><term>Infant, Newborn</term><term>Malaria (drug therapy)</term><term>Malawi</term><term>Mefloquine (adverse effects)</term><term>Mefloquine (therapeutic use)</term><term>Placentation (drug effects)</term><term>Pregnancy</term><term>Pregnancy Complications, Parasitic (drug therapy)</term><term>Prenatal Exposure Delayed Effects</term><term>Quinolines (adverse effects)</term><term>Quinolines (therapeutic use)</term><term>Zambia</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Amodiaquine (effets indésirables)</term><term>Amodiaquine (usage thérapeutique)</term><term>Antipaludiques (effets indésirables)</term><term>Antipaludiques (usage thérapeutique)</term><term>Artémisinines (effets indésirables)</term><term>Artémisinines (usage thérapeutique)</term><term>Association médicamenteuse</term><term>Burkina</term><term>Complications parasitaires de la grossesse (traitement médicamenteux)</term><term>Développement foetal ()</term><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Femelle</term><term>Fluorènes (effets indésirables)</term><term>Fluorènes (usage thérapeutique)</term><term>Ghana</term><term>Grossesse</term><term>Humains</term><term>Malawi</term><term>Méfloquine (effets indésirables)</term><term>Méfloquine (usage thérapeutique)</term><term>Nouveau-né</term><term>Paludisme (traitement médicamenteux)</term><term>Placentation ()</term><term>Poids de naissance ()</term><term>Quinoléines (effets indésirables)</term><term>Quinoléines (usage thérapeutique)</term><term>Zambie</term><term>Éthanolamines (effets indésirables)</term><term>Éthanolamines (usage thérapeutique)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Amodiaquine</term><term>Antimalarials</term><term>Artemisinins</term><term>Ethanolamines</term><term>Fluorenes</term><term>Mefloquine</term><term>Quinolines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amodiaquine</term><term>Antimalarials</term><term>Artemisinins</term><term>Ethanolamines</term><term>Fluorenes</term><term>Mefloquine</term><term>Quinolines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Burkina Faso</term><term>Drug Combinations</term><term>Ghana</term><term>Malawi</term><term>Zambia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Birth Weight</term><term>Fetal Development</term><term>Placentation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term><term>Pregnancy Complications, Parasitic</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Amodiaquine</term><term>Antipaludiques</term><term>Artémisinines</term><term>Fluorènes</term><term>Méfloquine</term><term>Quinoléines</term><term>Éthanolamines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications parasitaires de la grossesse</term><term>Paludisme</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Amodiaquine</term><term>Antipaludiques</term><term>Artémisinines</term><term>Fluorènes</term><term>Méfloquine</term><term>Quinoléines</term><term>Éthanolamines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant, Newborn</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Association médicamenteuse</term><term>Burkina</term><term>Développement foetal</term><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Femelle</term><term>Ghana</term><term>Grossesse</term><term>Humains</term><term>Malawi</term><term>Nouveau-né</term><term>Placentation</term><term>Poids de naissance</term><term>Zambie</term><term>Études de suivi</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Burkina Faso</term><term>Ghana</term><term>Malawi</term><term>Zambie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Asymptomatic and symptomatic malaria during pregnancy has consequences for both mother and her offspring. Unfortunately, there is insufficient information on the safety and efficacy of most antimalarials in pregnancy. Indeed, clinical trials assessing antimalarial treatments systematically exclude pregnancy for fear of teratogenicity and embryotoxicity. The little available information originates from South East Asia while in sub-Saharan Africa such information is still limited and needs to be provided.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><noCountry><name sortKey="Claeys, Yves" sort="Claeys, Yves" uniqKey="Claeys Y" first="Yves" last="Claeys">Yves Claeys</name><name sortKey="De Crop, Maaike" sort="De Crop, Maaike" uniqKey="De Crop M" first="Maaike" last="De Crop">Maaike De Crop</name><name sortKey="Halidou, Tinto" sort="Halidou, Tinto" uniqKey="Halidou T" first="Tinto" last="Halidou">Tinto Halidou</name><name sortKey="Kalanda, Gertrude" sort="Kalanda, Gertrude" uniqKey="Kalanda G" first="Gertrude" last="Kalanda">Gertrude Kalanda</name><name sortKey="Menten, Joris" sort="Menten, Joris" uniqKey="Menten J" first="Joris" last="Menten">Joris Menten</name><name sortKey="Mulenga, Modest" sort="Mulenga, Modest" uniqKey="Mulenga M" first="Modest" last="Mulenga">Modest Mulenga</name><name sortKey="Mutabingwa, Theonest" sort="Mutabingwa, Theonest" uniqKey="Mutabingwa T" first="Theonest" last="Mutabingwa">Theonest Mutabingwa</name><name sortKey="Mwakazanga, David" sort="Mwakazanga, David" uniqKey="Mwakazanga D" first="David" last="Mwakazanga">David Mwakazanga</name><name sortKey="Mwapasa, Victor" sort="Mwapasa, Victor" uniqKey="Mwapasa V" first="Victor" last="Mwapasa">Victor Mwapasa</name><name sortKey="Nambozi, Michael" sort="Nambozi, Michael" uniqKey="Nambozi M" first="Michael" last="Nambozi">Michael Nambozi</name><name sortKey="Phiri, Linda Kalilani" sort="Phiri, Linda Kalilani" uniqKey="Phiri L" first="Linda Kalilani" last="Phiri">Linda Kalilani Phiri</name><name sortKey="Ravinetto, Raffaella" sort="Ravinetto, Raffaella" uniqKey="Ravinetto R" first="Raffaella" last="Ravinetto">Raffaella Ravinetto</name><name sortKey="Schurmans, Celine" sort="Schurmans, Celine" uniqKey="Schurmans C" first="Céline" last="Schurmans">Céline Schurmans</name><name sortKey="Tagbor, Harry" sort="Tagbor, Harry" uniqKey="Tagbor H" first="Harry" last="Tagbor">Harry Tagbor</name><name sortKey="Thriemer, Kamala" sort="Thriemer, Kamala" uniqKey="Thriemer K" first="Kamala" last="Thriemer">Kamala Thriemer</name><name sortKey="Traore, Maminata" sort="Traore, Maminata" uniqKey="Traore M" first="Maminata" last="Traore">Maminata Traore</name><name sortKey="Valea, Innocent" sort="Valea, Innocent" uniqKey="Valea I" first="Innocent" last="Valea">Innocent Valea</name><name sortKey="Van Geertruyden, Jean Pierre" sort="Van Geertruyden, Jean Pierre" uniqKey="Van Geertruyden J" first="Jean-Pierre" last="Van Geertruyden">Jean-Pierre Van Geertruyden</name></noCountry><country name="Belgique"><noRegion><name sortKey="D Alessandro, Umberto" sort="D Alessandro, Umberto" uniqKey="D Alessandro U" first="Umberto" last="D'Alessandro">Umberto D'Alessandro</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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